Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
Identifieur interne : 004048 ( Main/Exploration ); précédent : 004047; suivant : 004049Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
Auteurs : Peter Kochunov [États-Unis] ; Neda Jahanshad [États-Unis] ; Emma Sprooten [États-Unis] ; Thomas E. Nichols [Royaume-Uni] ; René C. Mandl [Pays-Bas] ; Laura Almasy [États-Unis] ; Tom Booth [Royaume-Uni] ; Rachel M. Brouwer [Pays-Bas] ; Joanne E. Curran [États-Unis] ; Greig I. De Zubicaray [Australie] ; Rali Dimitrova [Royaume-Uni] ; Ravi Duggirala [États-Unis] ; Peter T. Fox [États-Unis] ; L. Elliot Hong [États-Unis] ; Bennett A. Landman [États-Unis] ; Hervé Lemaitre [France] ; Lorna M. Lopez [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Katie L. Mcmahon [Australie] ; Braxton D. Mitchell [États-Unis] ; Rene L. Olvera [États-Unis] ; Charles P. Peterson [États-Unis] ; John M. Starr [Royaume-Uni] ; Jessika E. Sussmann [Royaume-Uni] ; Arthur W. Toga [États-Unis] ; Joanna M. Wardlaw [Royaume-Uni] ; Margaret J. Wright [Australie] ; Susan N. Wright [États-Unis] ; Mark E. Bastin [Royaume-Uni] ; Andrew M. Mcintosh [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; René S. Kahn [Pays-Bas] ; Anouk Den Braber [Pays-Bas] ; Eco J. C. De Geus [Pays-Bas] ; Ian J. Deary [Royaume-Uni] ; Hilleke E. Hulshoff Pol [Pays-Bas] ; Douglas E. Williamson [États-Unis] ; John Blangero [États-Unis] ; Dennis Van T Ent [Pays-Bas] ; Paul M. Thompson [États-Unis] ; David C. Glahn [États-Unis]Source :
- NeuroImage : (Orlando, Fla.) [ 1053-8119 ] ; 2014.
Descripteurs français
- KwdFr :
- Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Anisotropie, Encéphale, Enfant, Femelle, Humains, Imagerie par tenseur de diffusion, Jeune adulte, Mâle, Méta-analyse comme sujet, Substance blanche, Formation image, Imagerie du tenseur de diffusion, Sujet âgé, Sujet âgé de 80 ans ou plus, Variation génétique.
English descriptors
- KwdEn :
- MESH :
Abstract
Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We use two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis the calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.
Url:
Affiliations:
- Australie, France, Pays-Bas, Royaume-Uni, États-Unis
- Californie, Hollande-Septentrionale, Utrecht (province), Écosse
- Amsterdam, Los Angeles, Orsay, Utrecht, Édimbourg
- Université d'Édimbourg, Université de Californie du Sud
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Martin</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QIMR Berghofer Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Centre for Advanced Imaging, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, University of Texas Health Science Center San Antonio</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>21 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P." last="Peterson">Charles P. Peterson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>24 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</s1><s3>GBR</s3><sZ>26 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QIMR Berghofer Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N." last="Wright">Susan N. Wright</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</s1><s3>GBR</s3><sZ>26 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>24 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Pol, Hilleke E Hulshoff" sort="Pol, Hilleke E Hulshoff" uniqKey="Pol H" first="Hilleke E. Hulshoff" last="Pol">Hilleke E. Hulshoff Pol</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E." last="Williamson">Douglas E. Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, University of Texas Health Science Center San Antonio</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>21 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0196930</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0196930 INIST</idno><idno type="RBID">Pascal:14-0196930</idno><idno type="wicri:Area/PascalFrancis/Corpus">000308</idno><idno type="wicri:Area/PascalFrancis/Curation">005B54</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000185</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000185</idno><idno type="wicri:doubleKey">1053-8119:2014:Kochunov P:multi:site:study</idno><idno type="wicri:Area/Main/Merge">004109</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043878</idno><idno type="RBID">PMC:4043878</idno><idno type="wicri:Area/Pmc/Corpus">002121</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002121</idno><idno type="wicri:Area/Pmc/Curation">001F75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F75</idno><idno type="wicri:Area/Pmc/Checkpoint">001451</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001451</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003630</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003630</idno><idno type="wicri:Area/PubMed/Curation">003517</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003517</idno><idno type="wicri:Area/PubMed/Checkpoint">003517</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003517</idno><idno type="wicri:Area/Ncbi/Merge">001888</idno><idno type="wicri:Area/Ncbi/Curation">001888</idno><idno type="wicri:Area/Ncbi/Checkpoint">001888</idno><idno type="wicri:doubleKey">1053-8119:2014:Kochunov P:multi:site:study</idno><idno type="wicri:Area/Main/Merge">003725</idno><idno type="wicri:Area/Main/Curation">004048</idno><idno type="wicri:Area/Main/Exploration">004048</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling</title><author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation></author><author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author><author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Statistics & Warwick Manufacturing Group, The University of Warwick</s1><s2>Coventry</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Coventry</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</s1><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University</wicri:noRegion></affiliation></author><author><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C." last="Mandl">René C. Mandl</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E." last="Curran">Joanne E. Curran</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>School of Psychology, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>24 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Research Imaging Institute, University of Texas Health Science Center San Antonio</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L. Elliot" last="Hong">L. Elliot Hong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A." last="Landman">Bennett A. Landman</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Electrical Engineering, Vanderbilt University</s1><s2>Nashville, TN</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Nashville, TN</wicri:noRegion></affiliation></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud</s1><s2>Orsay</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QIMR Berghofer Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Centre for Advanced Imaging, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, University of Texas Health Science Center San Antonio</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>21 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P." last="Peterson">Charles P. Peterson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>24 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</s1><s3>GBR</s3><sZ>26 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QIMR Berghofer Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N." last="Wright">Susan N. Wright</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh</s1><s3>GBR</s3><sZ>26 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>24 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>23 aut.</sZ><sZ>26 aut.</sZ><sZ>29 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Pol, Hilleke E Hulshoff" sort="Pol, Hilleke E Hulshoff" uniqKey="Pol H" first="Hilleke E. Hulshoff" last="Pol">Hilleke E. Hulshoff Pol</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>32 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E." last="Williamson">Douglas E. Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, University of Texas Health Science Center San Antonio</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>21 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Genetics, Texas Biomedical Research Institute</s1><s2>San Antonio, TX</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Antonio, TX</wicri:noRegion></affiliation></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Biological Psychology, VU University</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>31 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>25 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine</s1><s2>New Haven, CT</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Haven, CT</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anisotropy</term><term>Brain</term><term>Child</term><term>Diffusion Tensor Imaging</term><term>Diffusion tensor imaging</term><term>Encephalon</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Imaging</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>White Matter</term><term>White matter</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Encéphale</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Substance blanche</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anisotropy</term><term>Brain</term><term>Child</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>White Matter</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anisotropie</term><term>Encéphale</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Substance blanche</term><term>Formation image</term><term>Imagerie du tenseur de diffusion</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We use two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis the calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Hollande-Septentrionale</li><li>Utrecht (province)</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Los Angeles</li><li>Orsay</li><li>Utrecht</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name></noRegion><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><name sortKey="Curran, Joanne E" sort="Curran, Joanne E" uniqKey="Curran J" first="Joanne E." last="Curran">Joanne E. Curran</name><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name><name sortKey="Fox, Peter T" sort="Fox, Peter T" uniqKey="Fox P" first="Peter T." last="Fox">Peter T. Fox</name><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L. Elliot" last="Hong">L. Elliot Hong</name><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name><name sortKey="Landman, Bennett A" sort="Landman, Bennett A" uniqKey="Landman B" first="Bennett A." last="Landman">Bennett A. Landman</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L." last="Olvera">Rene L. Olvera</name><name sortKey="Peterson, Charles P" sort="Peterson, Charles P" uniqKey="Peterson C" first="Charles P." last="Peterson">Charles P. Peterson</name><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><name sortKey="Toga, Arthur W" sort="Toga, Arthur W" uniqKey="Toga A" first="Arthur W." last="Toga">Arthur W. Toga</name><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E." last="Williamson">Douglas E. Williamson</name><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N." last="Wright">Susan N. Wright</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name></noRegion><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><name sortKey="Booth, Tom" sort="Booth, Tom" uniqKey="Booth T" first="Tom" last="Booth">Tom Booth</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Dimitrova, Rali" sort="Dimitrova, Rali" uniqKey="Dimitrova R" first="Rali" last="Dimitrova">Rali Dimitrova</name><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><name sortKey="Mcintosh, Andrew M" sort="Mcintosh, Andrew M" uniqKey="Mcintosh A" first="Andrew M." last="Mcintosh">Andrew M. Mcintosh</name><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Sussmann, Jessika E" sort="Sussmann, Jessika E" uniqKey="Sussmann J" first="Jessika E." last="Sussmann">Jessika E. Sussmann</name><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Mandl, Rene C" sort="Mandl, Rene C" uniqKey="Mandl R" first="René C." last="Mandl">René C. Mandl</name></region><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><name sortKey="Kahn, Rene S" sort="Kahn, Rene S" uniqKey="Kahn R" first="René S." last="Kahn">René S. Kahn</name><name sortKey="Pol, Hilleke E Hulshoff" sort="Pol, Hilleke E Hulshoff" uniqKey="Pol H" first="Hilleke E. Hulshoff" last="Pol">Hilleke E. Hulshoff Pol</name><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name></country><country name="Australie"><noRegion><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name></noRegion><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name></country><country name="France"><noRegion><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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